1,269 research outputs found
Flight control electronics reliability/maintenance study
Collection and analysis of data are reported that concern the reliability and maintenance experience of flight control system electronics currently in use on passenger carrying jet aircraft. Two airlines B-747 airplane fleets were analyzed to assess the component reliability, system functional reliability, and achieved availability of the CAT II configuration flight control system. Also assessed were the costs generated by this system in the categories of spare equipment, schedule irregularity, and line and shop maintenance. The results indicate that although there is a marked difference in the geographic location and route pattern between the airlines studied, there is a close similarity in the reliability and the maintenance costs associated with the flight control electronics
Airborne Advanced Reconfigurable Computer System (ARCS)
A digital computer subsystem fault-tolerant concept was defined, and the potential benefits and costs of such a subsystem were assessed when used as the central element of a new transport's flight control system. The derived advanced reconfigurable computer system (ARCS) is a triple-redundant computer subsystem that automatically reconfigures, under multiple fault conditions, from triplex to duplex to simplex operation, with redundancy recovery if the fault condition is transient. The study included criteria development covering factors at the aircraft's operation level that would influence the design of a fault-tolerant system for commercial airline use. A new reliability analysis tool was developed for evaluating redundant, fault-tolerant system availability and survivability; and a stringent digital system software design methodology was used to achieve design/implementation visibility
Strategic Shift to a Diagnostic Model of Care in a Multi-Site Group Dental Practice.
BackgroundDocumenting standardized dental diagnostic terms represents an emerging change for how dentistry is practiced. We focused on a mid-sized dental group practice as it shifted to a policy of documenting patients' diagnoses using standardized terms in the electronic health record.MethodsKotter's change framework was translated into interview questions posed to the senior leadership in a mid-size dental group practice. In addition, quantitative content analyses were conducted on the written policies and forms before and after the implementation of standardized diagnosis documentation to assess the extent to which the forms and policies reflected the shift. Three reviewers analyzed the data individually and reached consensuses where needed.ResultsKotter's guiding change framework explained the steps taken to 97 percent utilization rate of the Electronic Health Record and Dental Diagnostic Code. Of the 96 documents included in the forms and policy analysis, 31 documents were officially updated but only two added a diagnostic element.ConclusionChange strategies established in the business literature hold utility for dental practices seeking diagnosis-centered care.Practical implicationsA practice that shifts to a diagnosis-driven care philosophy would be best served by ensuring that the change process follows a leadership framework that is calibrated to the organization's culture
Good practices for a literature survey are not followed by authors while preparing scientific manuscripts
The number of citations received by authors in scientific journals has become
a major parameter to assess individual researchers and the journals themselves
through the impact factor. A fair assessment therefore requires that the
criteria for selecting references in a given manuscript should be unbiased with
respect to the authors or the journals cited. In this paper, we advocate that
authors should follow two mandatory principles to select papers (later
reflected in the list of references) while studying the literature for a given
research: i) consider similarity of content with the topics investigated, lest
very related work should be reproduced or ignored; ii) perform a systematic
search over the network of citations including seminal or very related papers.
We use formalisms of complex networks for two datasets of papers from the arXiv
repository to show that neither of these two criteria is fulfilled in practice
Positron-molecule interactions: resonant attachment, annihilation, and bound states
This article presents an overview of current understanding of the interaction
of low-energy positrons with molecules with emphasis on resonances, positron
attachment and annihilation. Annihilation rates measured as a function of
positron energy reveal the presence of vibrational Feshbach resonances (VFR)
for many polyatomic molecules. These resonances lead to strong enhancement of
the annihilation rates. They also provide evidence that positrons bind to many
molecular species. A quantitative theory of VFR-mediated attachment to small
molecules is presented. It is tested successfully for selected molecules (e.g.,
methyl halides and methanol) where all modes couple to the positron continuum.
Combination and overtone resonances are observed and their role is elucidated.
In larger molecules, annihilation rates from VFR far exceed those explicable on
the basis of single-mode resonances. These enhancements increase rapidly with
the number of vibrational degrees of freedom. While the details are as yet
unclear, intramolecular vibrational energy redistribution to states that do not
couple directly to the positron continuum appears to be responsible for these
enhanced annihilation rates. Downshifts of the VFR from the vibrational mode
energies have provided binding energies for thirty species. Their dependence
upon molecular parameters and their relationship to positron-atom and
positron-molecule binding energy calculations are discussed. Feshbach
resonances and positron binding to molecules are compared with the analogous
electron-molecule (negative ion) cases. The relationship of VFR-mediated
annihilation to other phenomena such as Doppler-broadening of the gamma-ray
annihilation spectra, annihilation of thermalized positrons in gases, and
annihilation-induced fragmentation of molecules is discussed.Comment: 50 pages, 40 figure
Shadowing in the nuclear photoabsorption above the resonance region
A model based on the hadronic fluctuations of the real photon is developed to
describe the total photonucleon and photonuclear cross sections in the energy
region above the nucleon resonances. The hadronic spectral function of the
photon is derived including the finite width of vector-meson resonances and the
quark-antiquark continuum. The shadowing effect is evaluated considering the
effective interaction of the hadronic component with the bound nucleons within
a Glauber-Gribov multiple scattering theory. The low energy onset of the
shadowing effect is interpreted as a possible signature of a modification of
the hadronic spectral function in the nuclear medium. A decrease of the
-meson mass in nuclei is suggested for a better explanation of the
experimental data.Comment: 8 pages, 7 figure
Photoproduction of mesons in nuclei at GeV energies
In a transport model that combines initial state interactions of the photon
with final state interactions of the produced particles we present a
calculation of inclusive photoproduction of mesons in nuclei in the energy
range from 1 to 7 GeV. We give predictions for the photoproduction cross
sections of pions, etas, kaons, antikaons, and invariant mass
spectra in ^{12}C and ^{208}Pb. The effects of nuclear shadowing and final
state interaction of the produced particles are discussed in detail.Comment: Text added in summary in general reliability of the method,
references updated. Phys. Rev. C (2000) in pres
Chronic kidney disease care delivered by US family medicine and internal medicine trainees: results from an online survey
BACKGROUND: Complications of chronic kidney disease (CKD) contribute to morbidity and mortality. Consequently, treatment guidelines have been developed to facilitate early detection and treatment. However, given the high prevalence of CKD, many patients with early CKD are seen by non-nephrologists, who need to be aware of CKD complications, screening methods and treatment goals in order to initiate timely therapy and referral. METHODS: We performed a web-based survey to assess perceptions and practice patterns in CKD care among 376 family medicine and internal medicine trainees in the United States. Questions were focused on the identification of CKD risk factors, screening for CKD and associated co-morbidities, as well as management of anemia and secondary hyperparathyroidism in patients with CKD. RESULTS: Our data show that CKD risk factors are not universally recognized, screening for CKD complications is not generally taken into consideration, and that the management of anemia and secondary hyperparathyroidism poses major diagnostic and therapeutic difficulties for trainees. CONCLUSION: Educational efforts are needed to raise awareness of clinical practice guidelines and recommendations for patients with CKD among future practitioners
Cmr1/WDR76 defines a nuclear genotoxic stress body linking genome integrity and protein quality control
DNA replication stress is a source of genomic instability. Here we identify changed mutation rate 1 (Cmr1) as a factor involved in the response to DNA replication stress in Saccharomyces cerevisiae and show that Cmr1—together with Mrc1/Claspin, Pph3, the chaperonin containing TCP1 (CCT) and 25 other proteins—define a novel intranuclear quality control compartment (INQ) that sequesters misfolded, ubiquitylated and sumoylated proteins in response to genotoxic stress. The diversity of proteins that localize to INQ indicates that other biological processes such as cell cycle progression, chromatin and mitotic spindle organization may also be regulated through INQ. Similar to Cmr1, its human orthologue WDR76 responds to proteasome inhibition and DNA damage by relocalizing to nuclear foci and physically associating with CCT, suggesting an evolutionarily conserved biological function. We propose that Cmr1/WDR76 plays a role in the recovery from genotoxic stress through regulation of the turnover of sumoylated and phosphorylated proteins
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